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Patients with critical hepatic condition metabolize metronidazole slowly and gradually. This ends in the accumulation of metronidazole and its metabolites while in the plasma. Appropriately, for these kinds of people, metronidazole vaginal gel ought to be administered cautiously.

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METROGEL-VAGINAL affords minimal peak serum ranges and systemic publicity (AUCs) of metronidazole in comparison with five hundred mg oral metronidazole dosing. While these decreased levels of publicity are more unlikely to provide the widespread reactions witnessed with oral metronidazole, the potential for these together with other reactions cannot be excluded presently.

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